They say it takes about 400 hours of practice on the machine frame setups to become proficient in using them. I have what is considered to be a small to mid-arm sized setup. I have a Pfaff GrandQuilter for my machine and a HandiQuilter II style frame.
It took a few days to get the quilt loaded on the frame and everything set up to begin quilting. Of course all this is just a matter of learning how things work. I think it will be quite easy to do in the future.
The first real trouble I had was with thread tension. I think this is one of the most common types of problems for most folks in quilting, whether it be on a frame or just using the machine on a table. I had thread breakage problems and then thread loops underneath as I kept playing with the tension.
Today I went back at it. I changed needles to a top-stitch 100/16 needle, cleaned everything out very well, and then tried again to quilt. It worked! I do sometimes have thread breakage but each time I adjust things and I can now almost sew a full bobbin's worth without breakage.
I plan to get some 100/16 jeans needles at work today as I only had the top-stitch styled one, in that size, here. I've gone through four bobbins now. I like this! It will be much easier on me than wrestling the larger quilts at the table.
Below is a sample of my quilting. Nothing like taking a king size quilt and just "doing it" to it to learn how to quilt on a frame setup, huh! I always was the stubborn one. :)